Water-soluble curcumin 10% turmeric extract

1.Strongly launched water-soluble curcumin 10% turmeric extract

Water-Soluble Curcumin Curcumin is a natural orange-yellow pigment found in turmeric rhizomes. Widely used in food as a natural pigment, natural color in China for intestinal products, canned food, sauce products and other products in the United States: FDA approved curcumin as a food additive. In traditional medicine, it has also been used as a natural herbal medicine to protect the liver and delay inflammation. Recent studies have found that curcumin has anti-oxidant, anti-inflammatory, lipid-lowering, and anti-aging effects. It can also strengthen enzymes that metabolize free radicals in the body, prevent it from attacking intracellular DNA, and prevent mutation damage of cells, thereby achieving anti-cancer effects. However, curcumin is poorly absorbed orally, and most of it is excreted in its original form. Adults take 12g curcumin orally, the highest blood concentration is only 57.6ng / ml, and its bioavailability is only 1%. Curcumin belongs to the fourth category of low solubility and low permeability.

The US Food and Drug Administration (FDA) defines bioavailability as “the speed and extent to which an active ingredient or active site can reach the site of action in an effective form after being absorbed.” However, accurate determination of the active ingredient concentration at the site of action is not always feasible, so oral bioavailability (% F) is usually estimated from the active ingredient concentration in the blood circulation. That is, the blood drug concentration after oral administration and intravenous administration was measured at multiple time intervals, and the area under the blood drug concentration-time curve (AUC) was obtained. % F can be expressed by the following formula:% F = (AUC oral × intravenous dose) / (AUC intravenous × oral dose) × 10. So it is very important to improve the biophysical response rate of curcumin. New carrier to improve oral absorption of Curcumin. Turmeric is prepared in a nano-colloid manner, and the turmeric powder with an original particle size of about 22.75um is reduced to 0.19um, which can improve the solubility, and is lightfast and stable to heat. 30 mg of nano turmeric was wrapped in a film made of starch, and 100 mL of boiled water was taken by the subject, and then blood was drawn to test the content of turmeric in the plasma. The current water-soluble curcumin not only improves the bioavailability of turmeric, but also improves the qualitative characteristics of light and heat resistance, which greatly improves the application of curcumin in food additives and functional beverages.

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